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| Solon,Lílian Grace da Silva; Oliveira,Ana Isabel Maia de; Guerra,Gerlane Coelho Bernardo; Soares,Luiz Alberto Lira; Araújo,Aurigena Antunes de. |
| The aim of this study was to evaluate the quality of five different solid formulations of carbamazepine. The reference formulation was Tegretol® 200.00 mg (Novartis) and the others were: generic formulation of carbamazepine 200.00 mg (National Industry), similar formulation of carbamazepine 200.00 mg (National Industry), and two formulations of carbamazepine 200.00 mg acquired from two different compounding pharmacies. The latter consisted of capsules obtained in Natal, the capital city of the Brazilian State of Rio Grande do Norte. The quality of samples was evaluated through physical and physical-chemical tests, including: weight, diameter, thickness, content, dissolution, disintegration, hardness, friability and moisture. The results of friability... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Carbamazepine; Medicines/quality control; Generic medicines; Similar medicines; Medicines/magistral formulation. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300014 |
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| Cunha,Fabíola Pessoa da; Costa,Luana Janine Lopes da; Fernandes,Ana Josane Dantas; Souza,Tatiane Pereira de; Soares,Luiz Alberto Lira. |
| The purpose of this study was to evaluate the influences from variables of preparation on dry residue and total tannins from macerates of Astronium urundeuva barks. Thus, a 3 ² factorial design was used to study the importance of plant proportion (10, 15 and 20 %, w/v) and the ethanol concentration (40, 60 and 80 %, v/v) on the selected response. Mathematical models were fitted according to experimental data. The validated equations were used to generate response surfaces. The analysis of the surfaces showed that the optimum conditions to obtain extractive preparations with high extractive efficiency for tannins were: 10 % (w/v) of plant with ethanol 40 % (v/v) as solvent. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Astronium urundeuva; Extraction; Optimization; Factorial Design. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000300017 |
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| Galvão,Marcos Aurelio Morais; Arruda,Alice Oliveira de; Bezerra,Isabelle Cristinne Ferraz; Ferreira,Magda Rhayanny Assunção; Soares,Luiz Alberto Lira. |
| ABSTRACT The stem bark and pods of “jucá” are widely used in Brazilian folk medicine and, despite their therapeutic relevancies, there are insufficient reports about their quality control. Both herbal drugs from the species are rich in tannins, which showed a lot of biological and economic interest. Thus, the purpose of this study was to evaluate the method for quantification of tannins in the stem bark and pods from L. ferrea. The performance of the method was tested against the influence of the most relevant parameters (reaction time; amount of drug; type and amount of precipitationagents; and, concentration of the reagents). The procedure was validated according to the literature. After optimization, the experimental conditions were established as: 30... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Libidibia ferrea; Quality control; Spectrophotometry; Tannins. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100431 |
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| Ferreira,Magda Rhayanny Assunção; Santiago,Rosilene Rodrigues; Silva-Rocha,Walicyranison Plínio; Souza,Luanda Barbara Ferreira Canário de; Faria,Maria Graciela Icher; Mello,João Carlos Palazzo de; Langassner,Silvana Maria Zucolotto; Chaves,Guilherme Maranhão; Milan,Eveline Pipolo; Svidzinski,Terezinha Inez Estivalet; Soares,Luiz Alberto Lira. |
| The aim of this study was evaluate the in vitro antifungal activity of crude extracts from Eugenia uniflora, Libidibia ferrea and Psidium guajava. The extracts were obtained by turbo-extraction using water (AQ) or acetone-water (AC-W) (7:3, v/v) as solvents and lyophilized to obtain the crude extracts (CE). The CE were characterized by UV-Vis, TLC and HPLC. The activity of CEs was investigated against clinical isolates of Candida spp. and the Minimum Inhibitory Concentration (MIC), MIC50 and MIC90 were determinated. The analysis by TLC showed that all CEs presented polyphenols (flavonoids and tannins). The CEs from E. uniflora showed higher amount of polyphenols (30.35 ± 2.15%, AC-W) and the HPLC analysis revealed the tannins in all extracts. The CEs of E.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Medicinal plants; Herbal extracts; Polyphenols; Candida isolates; Oral candidiasis. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100608 |
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| Rodrigues,Rayllan de Oliveira; Damasceno,Gabriel Azevedo de Brito; Barreto,Stella Maria Andrade Gomes; Fernandes,Julia Morais; Telaprolu,Krishna Chaitanya; Rocha-Filho,Pedro Alves da; Soares,Luiz Alberto Lira; Ostrosky,Elissa Arantes; Sales,Valeria Soraya de Farias; Langassner,Silvana Maria Zucolotto; Ferrari,Márcio. |
| The purpose of this study was to evaluate the safety of Kalanchoe brasiliensis extract, followed by the development of an oil in water emulsion containing the K. brasiliensis leaves extract and evaluating its clinical moisturizing efficacy. The formulations containing sodium acrylates/ Beheneth-25 methacrylate Crosspolymer (and) hydrogenated polydecene (and) lauryl glucoside and 0.5% of extract were prepared. The extract was considered as non-irritating through skin irritant tests. The stability testing was carried out in different conditions for 90 days. The skin hydration was measured by capacitance measurement and transepidermal water loss using biophysical techniques. The results indicate that the formulation containing 0.5% of extract increased the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cosmetics/products; Kalanchoe brasiliensis/extract/safety evaluation; Kalanchoe brasiliensis/moisturizing efficacy; Stability studies; Brazil/plants. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400624 |
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